N-Acetyl cysteine in non-acetaminophen pediatric acute liver failure: Recent evidence !
نویسندگان
چکیده
منابع مشابه
N-acetyl cysteine in non-acetaminophen pediatric acute liver failure: recent evidence!
We read with interest the current consensus statement on management of acute liver failure in infants and children [1]. Pediatric acute liver failure (ALF) is a devastating disease in which previously healthy children rapidly lose hepatic function due to a variety of causes and become critically ill within days. Management is largely supportive and only few conditions are amenable to directed t...
متن کاملChronic acetaminophen exposure in pediatric acute liver failure.
BACKGROUND Acetaminophen (N-acetyl-p-aminophenol [APAP]) is a widely used medication that can cause hepatotoxicity. We examined characteristics and outcomes of children with chronic exposure (CE) to APAP in the multinational Pediatric Acute Liver Failure (PALF) Study. METHODS A total of 895 children enrolled from 2002 to 2009 were grouped by APAP exposure history as: CE (received multiple dos...
متن کاملDiscrepancies between N-Acetyl Cysteine Prescription based on Patient’s History and Plasma Acetaminophen Level
Background: Fatalities from acetaminophen poisoning are common, but they are preventable by timely treatment with N-acetyl cysteine (NAC). In many medical centers, NAC is prescribed in keeping with the ingested dose of the drug as revealed through medical history. It seems to significantly differ from the real indications of NAC administration based on plasma level of acetaminophen. Overtreat...
متن کاملUse of acetylcysteine for non-acetaminophen-induced acute liver failure.
The purpose of this review was to evaluate the effectiveness of acetylcysteine in the treatment of acute liver failure not related to acetaminophen. A search of MEDLINE April 2003 through May 2012 using the Pub Med database was conducted using the keywords acetylcysteine and non-acetaminophen-induced acute liver failure or acetylcysteine and liver failure. All human case reports, case series, a...
متن کاملRole of N-acetylcysteine treatment in non-acetaminophen-induced acute liver failure: A prospective study
BACKGROUND/AIMS Acute liver failure (ALF) is a rare but severe medical emergency. To date, there is no established treatment for non-acetaminophen-induced acute liver failure (NAI-ALF) other than liver transplantation, and little is known about the use of N-acetylcysteine (NAC) in NAI-ALF. A randomized case control study was conducted with the aim to determine the effect of NAC on the mortality...
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ژورنال
عنوان ژورنال: Indian Pediatrics
سال: 2013
ISSN: 0019-6061,0974-7559
DOI: 10.1007/s13312-013-0246-2